A more extensive and user friendly “Metalation Calculator II” has been released based on data from a new paper.
New Online Tool Streamlines Metal Occupancy Predictions in Cells
The E3B Metals-in-Biology Network has launched Metalation Calculator II, a significant upgrade to its online toolkit for predicting protein metalation states based on intracellular metal availability. This user-friendly version integrates fresh data from a recent study in Nature Communications, offering improved accuracy and accessibility.
This tool builds upon earlier E. coli calculators- covering aerobic, anaerobic, peroxide-stress, hyper-aerated, and M9 medium growth conditions- first described in Foster et al. (2022) Metallomics. Designed to help researchers model how different proteins acquire metals in vivo, it includes a revised interface and tutorial guidance to aid proper interpretation.
The project, led by Emeritus Professor Nigel Robinson at Durham University and supported by BBSRC funding, reflects the network’s commitment to accelerating mining insights from laboratory data to industrial biotech applications.
Researchers and practitioners can access the calculator on the dedicated E3B website. As this remains a beta release, developers welcome feedback to further refine functionality and performance.
Find the “Metalation Calculator II” on the E3B BBSRC NIBB website.